Publications

2017

Demberg LM*, Winkler J*, Wilde C*, Simon KU, Schön J, Rothemund S, Schöneberg T, Prömel S#, Liebscher I# (2017) Activation of Adhesion G Protein-coupled Receptors: Agonist specificity of Stachel sequence-derived peptides. Journal of Biological Chemistry 292:4383-4394. 

Scholz N*, Guan C*, Nieberler M*, Grotemeyer A*, Maiellaro I, Gao S, Beck S, Pawlak M, Sauer M, Asan E, Rothemund S, Winkler J, Prömel S, Nagel G, Langenhan T#, Kittel RJ# (2017) Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons. eLife 6. pii: e28360

Sorusch N, Bauß K, Plutniok J, Samanta A, Knapp B, Nagel-Wolfrum K, Wolfrum U (2017) Characterization of the ternary Usher syndrome SANS/ush2a/whirlin protein complex. Human Molecular Genetics 26:1157-1172. 

Zebrowski DC, Jensen CH, Becker R, Ferrazzi F, Baun C, Hvidsten S, Sheikh SP, Polizzotti BD, Andersen DC, Engel FB (2017) Cardiac injury of the newborn mammalian heart accelerates cardiomyocyte terminal differentiation. Scientific Reports 7: 8362. 

2016

Araç D, Sträter N, Seiradake E (2016) Understanding the Structural Basis of Adhesion GPCR Functions. Handbook of Experimental Pharmacology 234:67-82. 

Aust G, Zhu D, Van Meir EG, Xu L (2016) Adhesion GPCRs in Tumorigenesis. Handbook of Experimental Pharmacology 234:369-396. 

Backhaus P, Langenhan T, Neuser K (2016) Effects of transgenic expression of botulinum toxins in Drosophila. Journal of Neurogenetics 30:22-31.

Chang G-W, Hsiao C-C, Peng Y-M, Braga FAV, Kragten NAM, Remmerswaal EBM, van de Garde MDB, Straussberg R, König GM, Kostenis E, Knäuper V, Meyaard L, van Lier RAW, van Gisbergen KPJM, Lin H-H, and Hamann J (2016) The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells. Cell Reports 15:1757-70. 

Fischer L, Wilde C, Schöneberg T, Liebscher I (2016) Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133). BMC Genomics 17:609. 

Hamann J, Hsiao CC, Lee CS, Ravichandran KS, Lin HH (2016) Adhesion GPCRs as Modulators of Immune Cell Function. Handbook of Experimental Pharmacology 234:329-350. 

Hamann J, Petrenko AG. Introduction: History of the Adhesion GPCR Field. Handbook of Experimental Pharmacology 234:1-11. 

Kittel RJ#, Heckmann M# (2016) Synaptic Vesicle Proteins and Active Zone Plasticity. Front Synaptic Neurosci. 8:8. 

Knapp B, Wolfrum U (2016) Adhesion GPCR-Related Protein Networks. Handbook of Experimental Pharmacology 234:147-178. 

Kovacs P, Schöneberg T (2016) The Relevance of Genomic Signatures at Adhesion GPCR Loci in Humans. Handbook of Experimental Pharmacology 234:179-217. 

Langenhan T#, Piao X#, Monk KR# (2016) Adhesion G protein-coupled receptors in nervous system development and disease. Nature Reviews Neuroscience 17:550-61.

Liebscher I, Schöneberg T. Tethered Agonism: A Common Activation Mechanism of Adhesion GPCRs. Handbook of Experimental Pharmacology 234:111-125. 

Maiellaro I#, Lohse MJ, Kittel RJ#, Calebiro D# (2016) cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons. Cell Reports 17:1238-1246. 

Musa G, Engel FB, Niaudet C (2016) Heart Development, Angiogenesis, and Blood-Brain Barrier Function Is Modulated by Adhesion GPCRs. Handbook of Experimental Pharmacology 234:351-368. 

Nieberler M, Kittel RJ, Petrenko AG, Lin HH#, Langenhan T# (2016) Control of Adhesion GPCR Function Through Proteolytic Processing. Handbook of Experimental Pharmacology 234:83-109. 

Prömel S,  Fiedler F, Binder C, Winkler J, Schöneberg T, and Thor D (2016). Deciphering and modulating G protein signalling in C. elegans using the DREADD technology. Scientific Reports 6:28901.

Riemensperger T, Kittel RJ, Fiala A (2016) Optogenetics in Drosophila Neuroscience. In Bacterial Persistence. Methods in Molecular Biology 1408:167-75. 

Scholz N#, Monk KR, Kittel RJ, Langenhan T# (2016) Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors. Handbook of Experimental Pharmacology 234:221-247. 

Schöneberg T, Kleinau G, Brüser A (2016) What are they waiting for?-Tethered agonism in G protein-coupled receptors. Pharmacological Research. 108:9-15. 

Strutt D, Schnabel R, Fiedler F, Prömel S (2016) Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration. Handbook of Experimental Pharmacology 234:249-274. 

Wilde C, Fischer L, Lede V, Kirchberger J, Rothemund S, Schöneberg T, Liebscher I (2016). The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist. FASEB Journal 30:666-73.  

Winkler J, Prömel S (2016) The adhesion GPCR latrophilin – a novel signaling cascade in oriented cell division and anterior-posterior polarity. Worm 5(2) e1170274.

2015

Beck K, Ehmann N, Andlauer TF, Ljaschenko D, Strecker K, Fischer M, Kittel RJ, Raabe T (2015) Loss of the Coffin-Lowry syndrome-associated gene RSK2 alters ERK activity, synaptic function and axonal transport in Drosophila motoneurons. Disease Models & Mechanisms 8:1389-400.

Demberg LM, Rothemund S, Schöneberg T, and Liebscher I (2015) Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2. Biochemical & Biophysical Research Communications 464:743-747. 

Hamann J*,#, Aust G*, Arac D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin H-H, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T*, Schiöth HB*,# (2015) International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein-Coupled Receptors. Pharmacological Reviews 67:338–367.

Hsiao CC, Keysselt K, Chen HY, Sittig D, Hamann J, Lin HH, and Aust G (2015) The Adhesion GPCR CD97/ADGRE5 inhibits apoptosis. International Journal Biochemistry & Cell Biology 65:197-208. 

Langenhan T, Barr MM, Bruchas MR, Ewer J, Griffith LC, Maiellaro I, Taghert PH, White BH, and Monk KR (2015) Model Organisms in GPCR Research. Molecular Pharmacology 88:596-603.Download_Icon

Monk K, Hamann J, Langenhan T, Nijmeijer S, Schöneberg T, and Liebscher I (2015) Adhesion GPCRs: From In Vitro Pharmacology to In Vivo Mechanisms. Molecular Pharmacology 88:617-623. Download_Icon 

Müller A, Winkler J, Fiedler F, Sastradihardja T, Binder C, Schnabel R, Kungel J, Rothemund S, Hennig C, Schöneberg T, Prömel S (2015) Oriented Cell Division in the C. elegans Embryo Is Coordinated by G-Protein Signaling Dependent on the Adhesion GPCR LAT-1. PLoS Genetics 11(10):e1005624. 

Petersen SC, Luo R, Liebscher I, Giera S, Jeong S-J, Mogha A, Ghidinelli M, Feltri ML, Schöneberg T, Piao X, and Monk KR (2015) The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211. Neuron 85:755–769.

Scholz N, Gehring J, Guan C, Ljaschenko D, Fischer R, Lakshmanan V, Kittel RJ, and Langenhan T (2015) The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation. Cell Reports 11:866-874.

Schöneberg T, Liebscher I, Luo R, Monk KR, Piao X (2015) Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation. Journal of Receptors and Signal Transduction 35:220-3. 

2014

Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Annals of N Y Academy of Sciences 2014; 1333:43-64.

Liebscher I, Schön J, Petersen SC, Fischer L, Auerbach N, Demberg LM, Mogha A, Cöster M, Simon K-U, Rothemund S, Monk KR, and Schöneberg T (2014) A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133. Cell Reports 9:2018–2026.

Patra C, Monk KR, Engel FB. The multiple signaling modalities of adhesion G protein-coupled receptor GPR126 in development. Receptors & Clinical Investigation 2014; 1:90-97.

2012/2013

Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T (2012) Dissecting signaling and functions of adhesion G protein-coupled receptors. Annals of N Y Academy of Sciences 2 1276(1):1-25.

Mogha A, Benesh AE, Patra C, Engel FB, Schöneberg T, Liebscher I, Monk KR. Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation. Journal of Neuroscience 2013; 33(46):17986-94.

Patra C, van Amerongen MJ, Ghosh S, Ricciardi F, Sajjad A, Novoyatleva T, Mogha A, Monk KR, Mühlfeld C, Engel FB. Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. Proceedings of the National Academy of Sciences U S A. 2013; 110(42):16898-903.