Projects (1st funding period, 2015-2017)
The Research Unit comprises 8 projects + the mercator project concerning the signalling mechanism of Adhesion-GPCRs.
Project 1
Functional analysis of genetically encoded aGPCR signalling states
Project 2
Signaling mechanisms of the aGPCR Latrophilin in C. elegans
Project 3
Physiological role of aGPCR autoproteolysis
Project 4
Structural studies on extracellular and cytosolic domains of aGPCR
Project 5
Characterization of the aGPCR activation mechanism through their tethered agonist
Project 6
Functional characterization of the orphan aGPCR VLGR1/GPR98 in health and disease
Project 7
Elucidation of the functional role of Gpr126 during heart development
Project 8
Evaluation of CD97 signaling in transgenic mice
Mercator Project
The adhesion GPCR GPR56 – a key regulator of lymphocyte cytotoxicity