Projects (1^st funding period, 2015-2017)

The Research Unit comprises 8 projects + the mercator project concerning the signalling mechanism of Adhesion-GPCRs.

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Project 1
Functional analysis of genetically encoded aGPCR signalling states

Project 2
Signaling mechanisms of the aGPCR Latrophilin in C. elegans

Project 3
Physiological role of aGPCR autoproteolysis

Project 4
Structural studies on extracellular and cytosolic domains of aGPCR

Project 5
Characterization of the aGPCR activation mechanism through their tethered agonist

Project 6
Functional characterization of the orphan aGPCR VLGR1/GPR98 in health and disease

Project 7
Elucidation of the functional role of Gpr126 during heart development

Project 8
Evaluation of CD97 signaling in transgenic mice

Mercator Project
The adhesion GPCR GPR56 – a key regulator of lymphocyte cytotoxicity