Projects (2^nd funding period, 2018-2020)

In the 2^nd Funding period the Research Unit comprises 9 projects + the mercator project concerning the signalling mechanism of Adhesion-GPCRs.

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Project 01
Functional analysis of the adhesion GPCR class in Drosophila

Project 02
Physiological relevance and signaling mechanisms of the adhesion GPCR GPR110

Project 03
Interaction of adhesion GPCR signalling and ionotropic pathways during mechano-sensory signal transduction

Project 04
Structural studies on extracellular adhesion GPCR signaling

Project 05
The role of the adhesion G protein-coupled receptor GPR133/ADGRD1 in the mechano-sensitive tissues heart and bone

Project 06
VLGR1 signaling at focal adhesions and ICD release as a noncanonical signaling pathway of aGPCRs

Project 07
Delineating the role of CTF and NTF of Gpr126 in physiology and pathophysiology

Project 09
Adhesion GPCR signaling in hematopoietic stem and progenitor cells

Project 10
Adhesion GPCRs in inflammatory diseases of the human brain

Mercator Project
Contribution of aGPCR signals to the etiology of human tumorigenesis and -progression