Interaction of adhesion GPCR signalling and ionotropic pathways during mechano-sensory signal transduction
Building upon our observation that the adhesion G protein-coupled receptor (aGPCR) dCIRL acts as a metabotropic mechanosensor in Drosophila, this project will carry out a detailed investigation of the functional interaction between dCIRL and ionotropic mechanotransduction channels of the TRP (transient receptor potential) family. In order to judge the generality of such an interplay, we will focus on two mechanosensory systems: (i) the larval chordotonal organ, which detects external mechanical stimuli and (ii) specialized central neurons of adult Drosophila, which monitor internal osmolality.
Langenhan T (2019) Adhesion G protein-coupled receptors – candidate metabotropic mechanosensors and novel drug targets. Basic Clin Pharmacol Toxicol. doi: 10.1111/bcpt.13223. [Epub ahead of print].
Scholz N, Ehmann N, Sachidanandan D, Imig C, Cooper BH, Jahn O, Reim K, Brose N, Meyer J, Lamberty M, Altrichter S, Bormann A, Hallermann S, Pauli M, Heckmann M, Stigloher C, Langenhan T, Kittel RJ (2019) Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix. J Cell Biol. 218: 1011-1026.
Blanco-Redondo B, Langenhan T (2018) Parallel Genomic Engineering of Two Drosophila Genes Using Orthogonal attB/attP Sites. G3 (Bethesda). 8: 3109-3118.
Ehmann N, Owald D, Kittel RJ (2018) Drosophila active zones: From molecules to behaviour. Neuroscience Research. 127:14-24.