Book Publication

Handbook of Experimental Pharmacology 234

Adhesion G Protein-coupled Receptors
Molecular, Physiological and Pharmacological Principles in Health and Disease

Tobias Langenhan & Torsten Schöneberg
Institute of Biochemistry, Medical Faculty,
University of Leipzig, 

Product Information:
Bound Edition: number of pages 403

Publisher: Springer International Publishing AG
1st ed. 2016 

Language: Englisch
ISBN-10: 3319415212
ISBN-13: 978-3-319-41521-5
ISBN-eBook: 978-3-319-41523-9
ISSN: 0171-2004
DOI: 10.1007/978-3-319-41523-9

The chapters are authored by renowned experts in the aGPCR field and chart the current state of aGPCR research.


Table of Contents:
(Principal Investigators of the FOR 2149 are underlined)

Introduction: History of the Adhesion GPCR Field Jörg Hamann, Alexander G. Petrenko 1
Part I Molecular and Pharmacological Properties of Adhesion GPCRs
Classification, Nomenclature, and Structural Aspects of Adhesion GPCRs Arunkumar Krishnan, Saskia Nijmeijer, Chris de Graaf,
Helgi B. Schiöth
7TM Domain Structure of Adhesion GPCRs Chris de Graaf, Saskia Nijmeijer, Steffen Wolf, Oliver P. Ernst 43
Understanding the Structural Basis of Adhesion GPCR Functions Demet Arac¸, Norbert Sträter, Elena Seiradake 67
Control of Adhesion GPCR Function Through Proteolytic Processing Matthias Nieberler, Robert J. Kittel, Alexander G. Petrenko, Hsi-Hsien Lin, Tobias Langenhan 83
Tethered Agonism: A Common Activation Mechanism of Adhesion GPCRs Ines Liebscher, Torsten Schöneberg 111
Versatile Signaling Activity of Adhesion GPCRs Ayush Kishore, Randy A. Hall 127
Adhesion GPCR-Related Protein Networks Barbara Knapp, Uwe Wolfrum 147
The Relevance of Genomic Signatures at Adhesion GPCR Loci in Humans Peter Kovacs, Torsten Schöneberg 179
Part II Adhesion GPCRs as Pharmakotargets in Organ Function and Development
Adhesion GPCRs as a Putative Class of Metabotropic
Nicole Scholz, Kelly R. Monk, Robert J. Kittel, Tobias Langenhan 221
Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration David Strutt, Ralf Schnabel, Franziska Fiedler, Simone Prömel 249
Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination Séverine M. Sigoillot, Kelly R. Monk, Xianhua Piao, Fekrije Selimi, Breanne L. Harty 275
Control of Skeletal Muscle Cell Growth and Size Through Adhesion GPCRs James P. White 299
Adhesion GPCR Function in Pulmonary Development and Disease Marie-Gabrielle Ludwig, Klaus Seuwen, James P. Bridges 309
Adhesion GPCRs as Modulators of Immune Cell Function Jörg Hamann, Cheng-Chih Hsiao, Chang Sup Lee, Kodi S. Ravichandran, Hsi-Hsien Lin 329
Heart Development, Angiogenesis, and Blood-Brain Barrier Function Is Modulated by Adhesion GPCRs Gentian Musa, Felix B. Engel, Colin Niaudet 351
Adhesion GPCRs in Tumorigenesis Gabriela Aust, Dan Zhu, Erwin G. Van Meir, Lei Xu 369
Index   397